The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism

Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-i...

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Main Authors: Sha, Haibo, Sun, Shengyi, Francisco, Adams, Ehrhardt, Nicole, Xue, Zhen, Liu, Lei, Lawrence, Peter, Mattijssen, Frits, Guber, Robert, Panhwar, Muhammad S., Brenna, J. Thomas, Shi, Hang, Xue, Bingzhong, Kersten, Sander, Bensadoun, André, Péterfy, Miklós, Long, Qiaoming, Qi, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156539/
https://ncbi.nlm.nih.gov/pubmed/25066055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.06.015
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