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Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy

Cytotoxic T cells typically are expanded ex vivo in culture with IL-2 for adoptive immunotherapy. This culture period leads to a differentiated phenotype and acquisition of effector function, as well as a loss of in vivo proliferative capability and antitumor efficacy. Here, we report antigen-specif...

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Autori principali: Litterman, Adam J., Zellmer, David M., LaRue, Rebecca S., Jameson, Stephen C., Largaespada, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156517/
https://ncbi.nlm.nih.gov/pubmed/24852944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0038
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