Clade-Specific Flucytosine Resistance Is Due to a Single Nucleotide Change in the FUR1 Gene of Candida albicans

Population studies have indicated that natural resistance to flucytosine (5FC) in Candida albicans is limited to one of the five major clades, clade I. In addition, while 73% of clade I isolates are less susceptible to 5FC (MIC ≥ 0.5 μg/ml), only 2% of non-clade I isolates are less susceptible. In o...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Dodgson, Andrew R., Dodgson, Kirsty J., Pujol, Claude, Pfaller, Michael A., Soll, David R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2004
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415630/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15155225/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.6.2223-2227.2004
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