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The TRPM7 chanzyme is cleaved to release a chromatin modifying kinase
TRPM7 is a ubiquitous ion channel and kinase, a unique ‘chanzyme’, required for proper early embryonic development. It conducts Zn(2+), Mg(2+), Ca(2+) as well as monovalent cations, and contains a functional serine/threonine kinase at its carboxyl terminus. Here, we show that in normal tissues and c...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156102/ https://ncbi.nlm.nih.gov/pubmed/24855944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.046 |
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