Hepatic Differentiated Embryo-Chondrocyte-expressed Gene 1 (Dec1) Inhibits Sterol Regulatory Element-binding Protein-1c (Srebp-1c) Expression and Alleviates Fatty Liver Phenotype

Hepatic steatosis, characterized by ectopic hepatic triglyceride accumulation, is considered as the early manifestation of non-alcoholic fatty liver diseases (NAFLD). Increased SREBP-1c level and activity contribute to excessive hepatic triglyceride accumulation in NAFLD patients; however, negative...

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Hlavní autoři: Shen, Lian, Cui, Anfang, Xue, Yuan, Cui, Ying, Dong, Xueyu, Gao, Yong, Yang, Hao, Fang, Fude, Chang, Yongsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156064/
https://ncbi.nlm.nih.gov/pubmed/24993831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526343
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