The HIV-1 Integrase Mutant R263A/K264A Is 2-fold Defective for TRN-SR2 Binding and Viral Nuclear Import

Transportin-SR2 (Tnpo3, TRN-SR2), a human karyopherin encoded by the TNPO3 gene, has been identified as a cellular cofactor of HIV-1 replication, specifically interacting with HIV-1 integrase (IN). Whether this interaction mediates the nuclear import of HIV remains controversial. We previously chara...

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Bibliografiske detaljer
Main Authors: De Houwer, Stéphanie, Demeulemeester, Jonas, Thys, Wannes, Rocha, Susana, Dirix, Lieve, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155696/
https://ncbi.nlm.nih.gov/pubmed/25063804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533281
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