The Three Mycobacterium tuberculosis Antigen 85 Isoforms Have Unique Substrates and Activities Determined by Non-active Site Regions

The three isoforms of antigen 85 (A, B, and C) are the most abundant secreted mycobacterial proteins and catalyze transesterification reactions that synthesize mycolated arabinogalactan, trehalose monomycolate (TMM), and trehalose dimycolate (TDM), important constituents of the outermost layer of th...

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Detalhes bibliográficos
Main Authors: Backus, Keriann M., Dolan, Michael A., Barry, Conor S., Joe, Maju, McPhie, Peter, Boshoff, Helena I. M., Lowary, Todd L., Davis, Benjamin G., Barry, Clifton E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155671/
https://ncbi.nlm.nih.gov/pubmed/25028517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581579
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