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Arachidonic Acid Induces Direct Interaction of the p67(phox)-Rac Complex with the Phagocyte Oxidase Nox2, Leading to Superoxide Production
The phagocyte NADPH oxidase Nox2, heterodimerized with p22(phox) in the membrane, is dormant in resting cells but becomes activated upon cell stimulation to produce superoxide, a precursor of microbicidal oxidants. Nox2 activation requires two switches to be turned on simultaneously: a conformationa...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155656/ https://ncbi.nlm.nih.gov/pubmed/25056956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581785 |
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