Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer...

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Main Authors: Goldstein, Jacqueline I, Jarskog, L Fredrik, Hilliard, Chris, Alfirevic, Ana, Duncan, Laramie, Fourches, Denis, Huang, Hailiang, Lek, Monkol, Neale, Benjamin M, Ripke, Stephan, Shianna, Kevin, Szatkiewicz, Jin P, Tropsha, Alexander, van den Oord, Edwin JCG, Cascorbi, Ingolf, Dettling, Michael, Gazit, Ephraim, Goff, Donald C, Holden, Arthur L, Kelly, Deanna L, Malhotra, Anil K, Nielsen, Jimmi, Pirmohamed, Munir, Rujescu, Dan, Werge, Thomas, Levy, Deborah L, Josiassen, Richard C, Kennedy, James L, Lieberman, Jeffrey A, Daly, Mark J, Sullivan, Patrick F
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155508/
https://ncbi.nlm.nih.gov/pubmed/25187353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5757
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