Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Goldstein, Jacqueline I, Jarskog, L Fredrik, Hilliard, Chris, Alfirevic, Ana, Duncan, Laramie, Fourches, Denis, Huang, Hailiang, Lek, Monkol, Neale, Benjamin M, Ripke, Stephan, Shianna, Kevin, Szatkiewicz, Jin P, Tropsha, Alexander, van den Oord, Edwin JCG, Cascorbi, Ingolf, Dettling, Michael, Gazit, Ephraim, Goff, Donald C, Holden, Arthur L, Kelly, Deanna L, Malhotra, Anil K, Nielsen, Jimmi, Pirmohamed, Munir, Rujescu, Dan, Werge, Thomas, Levy, Deborah L, Josiassen, Richard C, Kennedy, James L, Lieberman, Jeffrey A, Daly, Mark J, Sullivan, Patrick F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155508/
https://ncbi.nlm.nih.gov/pubmed/25187353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5757
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