Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Goldstein, Jacqueline I, Jarskog, L Fredrik, Hilliard, Chris, Alfirevic, Ana, Duncan, Laramie, Fourches, Denis, Huang, Hailiang, Lek, Monkol, Neale, Benjamin M, Ripke, Stephan, Shianna, Kevin, Szatkiewicz, Jin P, Tropsha, Alexander, van den Oord, Edwin JCG, Cascorbi, Ingolf, Dettling, Michael, Gazit, Ephraim, Goff, Donald C, Holden, Arthur L, Kelly, Deanna L, Malhotra, Anil K, Nielsen, Jimmi, Pirmohamed, Munir, Rujescu, Dan, Werge, Thomas, Levy, Deborah L, Josiassen, Richard C, Kennedy, James L, Lieberman, Jeffrey A, Daly, Mark J, Sullivan, Patrick F
التنسيق: Artigo
اللغة:Inglês
منشور في: 2014
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155508/
https://ncbi.nlm.nih.gov/pubmed/25187353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5757
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