Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency

XRCC4-like factor (XLF/Cernunnos) is a component of the nonhomologous end-joining (NHEJ) pathway of double-strand DNA break repair. XLF-deficient patients develop a severe progressive lymphocytopenia. Although NHEJ is required for V(D)J recombination and lymphocyte development, XLF-deficient mice ha...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Avagyan, Serine, Churchill, Michael, Yamamoto, Kenta, Crowe, Jennifer L., Li, Chen, Lee, Brian J., Zheng, Tian, Mukherjee, Siddhartha, Zha, Shan
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2014
主題:
Immunobiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155271/
https://ncbi.nlm.nih.gov/pubmed/25075129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-574863
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍