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Tracing the Evolution of the p53 Tetramerization Domain

The tetrameric transcription factors p53, p63, and p73 evolved from a common ancestor and play key roles in tumor suppression and development. Surprisingly, p63 and p73 require a second helix in their tetramerization domain for the formation of stable tetramers that is absent in human p53, raising q...

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Detalhes bibliográficos
Main Authors: Joerger, Andreas C., Wilcken, Rainer, Andreeva, Antonina
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155161/
https://ncbi.nlm.nih.gov/pubmed/25185827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.07.010
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