AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt-MDM2-Foxo3a Signaling Axis

In cancer cells, the epithelial-mesenchymal transition (EMT) confers the ability to invade basement membranes and metastasize to distant sites, establishing it as an appealing target for therapeutic intervention. Here, we report a novel function of the master metabolic kinase AMPK in suppressing EMT...

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Detalhes bibliográficos
Main Authors: Chou, Chih-Chien, Lee, Kuen-Haur, Lai, I-Lu, Wang, Dasheng, Mo, Xiaokui, Kulp, Samuel K., Shapiro, Charles L., Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155002/
https://ncbi.nlm.nih.gov/pubmed/24994714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0135
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