Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector

Ideal cancer gene therapies should have high tumor specificity and efficacy, and allow systemic administration to target metastases. We recently developed a bi-directional, two-step transcriptional amplification (TSTA) system driven by the tumor-specific Survivin promoter (pSurv) to amplify the corr...

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Detaylı Bibliyografya
Asıl Yazarlar: Ahn, B-C, Ronald, JA, Kim, YI, Katzenberg, R, Singh, A, Paulmurugan, R, Ray, S, Hofmann, LV, Gambhir, SS
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154811/
https://ncbi.nlm.nih.gov/pubmed/21307888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.5
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