Bipartite Recognition of DNA by TCF/Pangolin Is Remarkably Flexible and Contributes to Transcriptional Responsiveness and Tissue Specificity of Wingless Signaling

The T-cell factor (TCF) family of transcription factors are major mediators of Wnt/β-catenin signaling in metazoans. All TCFs contain a High Mobility Group (HMG) domain that possesses specific DNA binding activity. In addition, many TCFs contain a second DNA binding domain, the C-clamp, which binds...

Full description

Saved in:
Bibliographic Details
Main Authors: Archbold, Hilary C., Broussard, Chris, Chang, Mikyung V., Cadigan, Ken M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154663/
https://ncbi.nlm.nih.gov/pubmed/25188465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004591
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items