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Activation of Wingless targets requires bipartite recognition of DNA by TCF

Specific recognition of DNA by transcription factors is essential for precise gene regulation. In Wingless (Wg) signaling in Drosophila, target gene regulation is controlled by TCF, which binds to specific DNA sequences through a HMG domain [1]. However, there is considerable degeneracy in what cons...

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Detalhes bibliográficos
Main Authors: Chang, Mikyung V., Chang, Jinhee L., Gangopadhyay, Anu, Shearer, Andrew, Cadigan, Ken M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105462/
https://ncbi.nlm.nih.gov/pubmed/19062282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2008.10.047
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