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Sulfaphenazole and α-naphthoflavone attenuate the metabolism of the synthetic cannabinoids JWH-018 and AM2201 found in K2/Spice

“K2” or “Spice” is an emerging drug of abuse that is laced with psychoactive synthetic cannabinoids JWH-018 and AM2201. Previous studies have identified hydroxylated (OH) and carboxylated (COOH) species as primary human metabolites, and kinetic studies have implicated CYP2C9 and -1A2 as major hepati...

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Bibliografske podrobnosti
Main Authors: Chimalakonda, Krishna C., James, Laura P., Radominska-Pandya, Anna, Moran, Jeffery H.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154622/
https://ncbi.nlm.nih.gov/pubmed/24329780
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