Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands

Abuse of synthetic cannabinoids (SCs), such as [1-naphthalenyl-(1-pentyl-1H-indol-3-yl]-methanone (JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (AM2201), is increasing at an alarming rate. Although very little is known about the metabolism and toxicology of these popular...

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Main Authors: Chimalakonda, Krishna C., Seely, Kathryn A., Bratton, Stacie M., Brents, Lisa K., Moran, Cindy L., Endres, Gregory W., James, Laura P., Hollenberg, Paul F., Prather, Paul L., Radominska-Pandya, Anna, Moran, Jeffery H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477201/
https://ncbi.nlm.nih.gov/pubmed/22904561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.047530
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