Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

Quantitative assays for human DNA and mRNA were used to examine the paradox that intravenously (i.v.) infused human multipotent stromal cells (hMSCs) can enhance tissue repair without significant engraftment. After 2 × 10(6) hMSCs were i.v. infused into mice, most of the cells were trapped as emboli...

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Bibliografiske detaljer
Main Authors: Lee, Ryang Hwa, Pulin, Andrey A., Seo, Min Jeong, Kota, Daniel J., Ylostalo, Joni, Larson, Benjamin L., Semprun-Prieto, Laura, Delafontaine, Patrice, Prockop, Darwin J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154377/
https://ncbi.nlm.nih.gov/pubmed/19570514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.05.003
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