Mechanisms of mesenchymal stem/stromal cell function

por Spees, Jeffrey L., Lee, Ryang Hwa, Gregory, Carl A.
Publicado no Stem Cell Res Ther (2016)

Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs

por Prockop, Darwin J., Oh, Joo Youn, Lee, Ryang Hwa
Publicado no Mol Ther (2017)

TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity

por Kota, Daniel J., Wiggins, Lindsey L., Yoon, Nara, Lee, Ryang Hwa
Publicado em 2013

Stanniocalcin-1 Attenuates Ischemic Cardiac Injury and Response of Differentiating Monocytes/Macrophages to Inflammatory Stimuli

por Mohammadipoor, Arezoo, Lee, Ryang Hwa, Prockop, Darwin J, Bartosh, Thomas J
Publicado no Transl Res (2016)

Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren's Syndrome

por Hai, Bo, Shigemoto-Kuroda, Taeko, Zhao, Qingguo, Lee, Ryang Hwa, Liu, Fei
Publicado no Stem Cells Int (2018)

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages

por Choi, Hosoon, Lee, Ryang Hwa, Bazhanov, Nikolay, Oh, Joo Youn, Prockop, Darwin J.
Publicado em 2011

The CD34-like protein PODXL and α6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice

por Lee, Ryang Hwa, Seo, Min Jeong, Pulin, Andrey A., Gregory, Carl A., Ylostalo, Joni, Prockop, Darwin J.
Publicado em 2009

In Vitro Macrophage Assay Predicts the In Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells

por Pacienza, Natalia, Lee, Ryang Hwa, Bae, Eun-Hye, Kim, Dong-ki, Liu, Qisong, Prockop, Darwin J., Yannarelli, Gustavo
Publicado no Mol Ther Methods Clin Dev (2018)

Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea

por Oh, Joo Youn, Choi, Hosoon, Lee, Ryang Hwa, Roddy, Gavin W, Ylöstalo, Joni H, Wawrousek, Eric, Prockop, Darwin J
Publicado em 2012

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

por Oh, Joo Youn, Roddy, Gavin W., Choi, Hosoon, Lee, Ryang Hwa, Ylöstalo, Joni H., Rosa, Robert H., Prockop, Darwin J.
Publicado em 2010

Intra-articular Injection of Human Mesenchymal Stem Cells (MSCs) Promote Rat Meniscal Regeneration by Being Activated to Express Indian Hedgehog that Enhances Expression of Type II...

por Horie, Masafumi, Choi, Hosoon, Lee, Ryang Hwa, Reger, Roxanne L., Ylostalo, Joni, Muneta, Takeshi, Sekiya, I chiro, Prockop, Darwin J.
Publicado em 2012

Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice

por Lee, Ryang Hwa, Seo, Min Jeong, Reger, Roxanne L., Spees, Jeffrey L., Pulin, Andrey A., Olson, Scott D., Prockop, Darwin J.
Publicado em 2006

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

por Bartosh, Thomas J., Ylöstalo, Joni H., Mohammadipoor, Arezoo, Bazhanov, Nikolay, Coble, Katie, Claypool, Kent, Lee, Ryang Hwa, Choi, Hosoon, Prockop, Darwin J.
Publicado em 2010

TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo

por Lee, Ryang Hwa, Yu, Ji Min, Foskett, Andrea M., Peltier, Grant, Reneau, John C., Bazhanov, Nikolay, Oh, Joo Youn, Prockop, Darwin J.
Publicado no Proc Natl Acad Sci U S A (2014)

Intravenous Mesenchymal Stem Cells Prevented Rejection of Allogeneic Corneal Transplants by Aborting the Early Inflammatory Response

por Oh, Joo Youn, Lee, Ryang Hwa, Yu, Ji Min, Ko, Jung Hwa, Lee, Hyun Ju, Ko, Ah Young, Roddy, Gavin W, Prockop, Darwin J
Publicado em 2012

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

por Lee, Ryang Hwa, Pulin, Andrey A., Seo, Min Jeong, Kota, Daniel J., Ylostalo, Joni, Larson, Benjamin L., Semprun-Prieto, Laura, Delafontaine, Patrice, Prockop, Darwin J.
Publicado em 2009

Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It

por Kim, Dong-Ki, Choi, Hosoon, Nishida, Hidetaka, Oh, Joo Youn, Gregory, Carl, Lee, Ryang Hwa, Yu, Ji Min, Watanabe, Jun, An, Su Yeon, Bartosh, Thomas J., Prockop, Darwin J.
Publicado no PLoS One (2016)

MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs

por Zhao, Qingguo, Gregory, Carl A., Lee, Ryang Hwa, Reger, Roxanne L., Qin, Lizheng, Hai, Bo, Park, Min Sung, Yoon, Nara, Clough, Bret, McNeill, Eoin, Prockop, Darwin J., Liu, Fei
Publicado no Proc Natl Acad Sci U S A (2015)

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

por Shigemoto-Kuroda, Taeko, Oh, Joo Youn, Kim, Dong-ki, Jeong, Hyun Jeong, Park, Se Yeon, Lee, Hyun Ju, Park, Jong Woo, Kim, Tae Wan, An, Su Yeon, Prockop, Darwin J., Lee, Ryang Hwa
Publicado no Stem Cell Reports (2017)

Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner

por Song, Hyun Beom, Park, Se Yeon, Ko, Jung Hwa, Park, Jong Woo, Yoon, Chang Ho, Kim, Dong Hyun, Kim, Jeong Hun, Kim, Mee Kum, Lee, Ryang Hwa, Prockop, Darwin J., Oh, Joo Youn
Publicado no Mol Ther (2018)