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Human mesenchymal stem/stromal cells (hMSCs) cultured as spheroids are self-activated to produce prostaglandin E2 (PGE2) that directs stimulated macrophages into an anti-inflammatory phenotype

Culturing cells in 3D provides an insight into their characteristics in vivo. We previously reported that human mesenchymal stem/stromal cells (hMSCs) cultured as 3D spheroids acquire enhanced anti-inflammatory properties. Here we explored the effects of hMSC spheroids on macrophages that are critic...

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Detalhes bibliográficos
Main Authors: Ylöstalo, Joni H., Bartosh, Thomas J., Coble, Katie, Prockop, Darwin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448872/
https://ncbi.nlm.nih.gov/pubmed/22865689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1191
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