Dynamic compaction of human mesenchymal stem/precursor cells (MSC) into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6 and STC1)

Human mesenchymal stem/precursor cells (MSC) are similar to some other stem/progenitor cells in that they compact into spheres when cultured in hanging drops or on non-adherent surfaces. Assembly of MSC into spheres alters many of their properties, including enhanced secretion of factors that mediat...

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Detalhes bibliográficos
Main Authors: Bartosh, Thomas J., Ylöstalo, Joni H., Bazhanov, Nikolay, Kuhlman, Jessica, Prockop, Darwin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834191/
https://ncbi.nlm.nih.gov/pubmed/23922312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1499
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