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Synthesis of α-Ketoester- and α-Hydroxyester-Substituted Isoindazoles via the Thermodynamic Coarctate Cyclization of Ester-Terminated Azo-Ene-Yne Systems

The synthesis of isoindazoles bearing α-ketoester and α-hydroxyester groups via the coarctate cyclization of ester terminated azo-ene-yne precursors is described. Whereas previous studies on isoindazole formation have shown the reaction to proceed through a kinetic coarctate pathway, functionalizati...

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Detalhes bibliográficos
Main Authors: McClintock, Sean P., Forster, Nathan, Herges, Rainer, Haley, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154358/
https://ncbi.nlm.nih.gov/pubmed/19642649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo9011283
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