Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro: Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein

Background: Acrolein is a ubiquitous environmental hazard to human health. Acrolein has been reported to activate the DNA damage response and induce apoptosis. However, little is known about the effects of acrolein on cellular senescence. Objectives: We examined whether acrolein induces cellular sen...

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Main Authors: Jang, Jun-Ho, Bruse, Shannon, Huneidi, Salam, Schrader, Ronald M., Monick, Martha M., Lin, Yong, Carter, A. Brent, Klingelhutz, Aloysius J., Nyunoya, Toru
Formato: Artigo
Idioma:Inglês
Publicado: NLM-Export 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154210/
https://ncbi.nlm.nih.gov/pubmed/24747221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1306911
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