Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro: Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein

Background: Acrolein is a ubiquitous environmental hazard to human health. Acrolein has been reported to activate the DNA damage response and induce apoptosis. However, little is known about the effects of acrolein on cellular senescence. Objectives: We examined whether acrolein induces cellular sen...

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Hlavní autoři: Jang, Jun-Ho, Bruse, Shannon, Huneidi, Salam, Schrader, Ronald M., Monick, Martha M., Lin, Yong, Carter, A. Brent, Klingelhutz, Aloysius J., Nyunoya, Toru
Médium: Artigo
Jazyk:Inglês
Vydáno: NLM-Export 2014
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154210/
https://ncbi.nlm.nih.gov/pubmed/24747221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1306911
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