Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion

The pathobiology of irritable bowel syndrome (IBS) is multifaceted. We aimed to identify candidate genes predisposing to quantitative traits in IBS. In 30 healthy volunteers, 30 IBS-constipation, and 64 IBS-diarrhea patients, we measured bowel symptoms, bile acid (BA) synthesis (serum 7α-hydroxy-4-c...

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Detalhes bibliográficos
Main Authors: Camilleri, Michael, Shin, Andrea, Busciglio, Irene, Carlson, Paula, Acosta, Andres, Bharucha, Adil E., Burton, Duane, Lamsam, Jesse, Lueke, Alan, Donato, Leslie J., Zinsmeister, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154122/
https://ncbi.nlm.nih.gov/pubmed/25012842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00178.2014
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