Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

BACKGROUND: Mitochondrial DNA (mtDNA) deletions cause disease and accumulate during aging, yet our understanding of the molecular mechanisms underlying their formation remains rudimentary. Guanine-quadruplex (GQ) DNA structures are associated with nuclear DNA instability in cancer; recent evidence i...

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Detalhes bibliográficos
Main Authors: Dong, Dawei W, Pereira, Filipe, Barrett, Steven P, Kolesar, Jill E, Cao, Kajia, Damas, Joana, Yatsunyk, Liliya A, Johnson, F Brad, Kaufman, Brett A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153896/
https://ncbi.nlm.nih.gov/pubmed/25124333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-677
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