Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

AIMS: Kidney cells in patients with diabetic nephropathy are reported to be senescent. However, the mechanisms that regulate cellular senescence in the diabetic kidney are still unknown. In the present study, we evaluated the contribution of high glucose to renal cell senescence in streptozotocin (S...

Full description

Saved in:
Bibliographic Details
Main Authors: Kitada, Kento, Nakano, Daisuke, Ohsaki, Hiroyuki, Hitomi, Hirofumi, Minamino, Tohru, Yatabe, Junichi, Felder, Robin A., Mori, Hirohito, Masaki, Tsutomu, Kobori, Hiroyuki, Nishiyama, Akira
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153757/
https://ncbi.nlm.nih.gov/pubmed/24996978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdiacomp.2014.05.010
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items