Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

AIMS: Kidney cells in patients with diabetic nephropathy are reported to be senescent. However, the mechanisms that regulate cellular senescence in the diabetic kidney are still unknown. In the present study, we evaluated the contribution of high glucose to renal cell senescence in streptozotocin (S...

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Bibliografski detalji
Glavni autori: Kitada, Kento, Nakano, Daisuke, Ohsaki, Hiroyuki, Hitomi, Hirofumi, Minamino, Tohru, Yatabe, Junichi, Felder, Robin A., Mori, Hirohito, Masaki, Tsutomu, Kobori, Hiroyuki, Nishiyama, Akira
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153757/
https://ncbi.nlm.nih.gov/pubmed/24996978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdiacomp.2014.05.010
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