Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Noonan syndrome (NS) and LEOPARD syndrome (LS) cause congenital afflictions such as short stature, hypertelorism and heart defects. More than 50% of NS and almost all of LS cases are caused by activating and inactivating mutations of the phosphatase Shp2, respectively. How these biochemically opposi...

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Main Authors: Paardekooper Overman, Jeroen, Preisinger, Christian, Prummel, Karin, Bonetti, Monica, Giansanti, Piero, Heck, Albert, den Hertog, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153654/
https://ncbi.nlm.nih.gov/pubmed/25184253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106682
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