Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates

The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primate...

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Main Authors: Yang, Xiaoxia, Morris, Suzanne M., Gearhart, Jeffery M., Ruark, Christopher D., Paule, Merle G., Slikker, William, Mattison, Donald R., Vitiello, Benedetto, Twaddle, Nathan C., Doerge, Daniel R., Young, John F., Fisher, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153582/
https://ncbi.nlm.nih.gov/pubmed/25184666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106101
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