Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates

The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primate...

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Autors principals: Yang, Xiaoxia, Morris, Suzanne M., Gearhart, Jeffery M., Ruark, Christopher D., Paule, Merle G., Slikker, William, Mattison, Donald R., Vitiello, Benedetto, Twaddle, Nathan C., Doerge, Daniel R., Young, John F., Fisher, Jeffrey W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153582/
https://ncbi.nlm.nih.gov/pubmed/25184666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106101
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