Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate

Juvenile male rhesus monkeys treated with methylphenidate hydrochloride (MPH) to evaluate genetic and behavioral toxicity were observed after 14 mo of treatment to have delayed pubertal progression with impaired testicular descent and reduced testicular volume. Further evaluation of animals dosed or...

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Główni autorzy: Mattison, Donald R., Plant, Tony M., Lin, Hui-Min, Chen, Hung-Chia, Chen, James J., Twaddle, Nathan C., Doerge, Daniel, Slikker, William, Patton, Ralph E., Hotchkiss, Charlotte E., Callicott, Ralph J., Schrader, Steven M., Turner, Terry W., Kesner, James S., Vitiello, Benedetto, Petibone, Dayton M., Morris, Suzanne M.
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2011
Hasła przedmiotowe:
Biological Sciences
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182701/
https://ncbi.nlm.nih.gov/pubmed/21930929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102187108
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