Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate

Juvenile male rhesus monkeys treated with methylphenidate hydrochloride (MPH) to evaluate genetic and behavioral toxicity were observed after 14 mo of treatment to have delayed pubertal progression with impaired testicular descent and reduced testicular volume. Further evaluation of animals dosed or...

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Détails bibliographiques
Auteurs principaux: Mattison, Donald R., Plant, Tony M., Lin, Hui-Min, Chen, Hung-Chia, Chen, James J., Twaddle, Nathan C., Doerge, Daniel, Slikker, William, Patton, Ralph E., Hotchkiss, Charlotte E., Callicott, Ralph J., Schrader, Steven M., Turner, Terry W., Kesner, James S., Vitiello, Benedetto, Petibone, Dayton M., Morris, Suzanne M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2011
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182701/
https://ncbi.nlm.nih.gov/pubmed/21930929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102187108
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