Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells

BACKGROUND: Inducing endoplasmic reticulum (ER) stress is a novel strategy used to treat malignancies. Inhibition of histone deacetylase (HDAC) 6 by the HDAC inhibitor panobinostat hinders the refolding of unfolded proteins by increasing the acetylation of heat shock protein 90. We investigated whet...

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Hlavní autoři: Sato, Akinori, Asano, Takako, Isono, Makoto, Ito, Keiichi, Asano, Tomohiko
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153447/
https://ncbi.nlm.nih.gov/pubmed/25176354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2490-14-71
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