NS19504: A Novel BK Channel Activator with Relaxing Effect on Bladder Smooth Muscle Spontaneous Phasic Contractions

Large-conductance Ca(2+)-activated K(+) channels (BK, K(Ca)1.1, MaxiK) are important regulators of urinary bladder function and may be an attractive therapeutic target in bladder disorders. In this study, we established a high-throughput fluorometric imaging plate reader–based screening assay for BK...

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Autors principals: Nausch, Bernhard, Rode, Frederik, Jørgensen, Susanne, Nardi, Antonio, Korsgaard, Mads P. G., Hougaard, Charlotte, Bonev, Adrian D., Brown, William D., Dyhring, Tino, Strøbæk, Dorte, Olesen, Søren-Peter, Christophersen, Palle, Grunnet, Morten, Nelson, Mark T., Rønn, Lars C. B.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2014
Matèries:
Drug Discovery and Translational Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152884/
https://ncbi.nlm.nih.gov/pubmed/24951278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.212662
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