Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders

There is growing evidence that activation of metabotropic glutamate receptor 4 (mGlu(4)) leads to anxiolytic- and antipsychotic-like efficacy in rodent models, yet its relevance to depression-like reactivity remains unclear. Here, we present the pharmacological evaluation of ADX88178 [5-methyl-N-(4-...

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Detalhes bibliográficos
Main Authors: Kalinichev, Mikhail, Le Poul, Emmanuel, Boléa, Christelle, Girard, Françoise, Campo, Brice, Fonsi, Massimiliano, Royer-Urios, Isabelle, Browne, Susan E., Uslaner, Jason M., Davis, Matthew J., Raber, Jacob, Duvoisin, Robert, Bate, Simon T., Reynolds, Ian J., Poli, Sonia, Celanire, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152882/
https://ncbi.nlm.nih.gov/pubmed/24947466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214437
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