A Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its Derivatives

Tamoxifen (Tam) is a selective estrogen receptor modulator used to inhibit breast tumor growth. Tam can be directly N-glucuronidated via the tertiary amine group or O-glucuronidated after cytochrome P450–mediated hydroxylation. In this study, the glucuronidation of Tam and its hydroxylated and/or ch...

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Main Authors: Greer, Aleksandra K., Dates, Centdrika R., Starlard-Davenport, Athena, Edavana, Vineetha K., Bratton, Stacie M., Dhakal, Ishwori B., Finel, Moshe, Kadlubar, Susan A., Radominska-Pandya, Anna
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152870/
https://ncbi.nlm.nih.gov/pubmed/24917585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.058016
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