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Tissue specific and age dependent effects of global Mdm2 loss
Mdm2, an E3 ubiquitin ligase, negatively regulates the tumor suppressor p53. In this study, we utilized a conditional Mdm2 allele, Mdm2(FM), and a CreER Tamoxifen inducible recombination system to examine the effects of global Mdm2 loss in adult mice. Two different Tamoxifen injection regimens cause...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151977/ https://ncbi.nlm.nih.gov/pubmed/24789767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4368 |
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