Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential

Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and myelocytomatosis oncogene (c-MYC). However, some induced pluripotent stem cells (iPSCs) exhibit de...

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Hauptverfasser: Ohnuki, Mari, Tanabe, Koji, Sutou, Kenta, Teramoto, Ito, Sawamura, Yuka, Narita, Megumi, Nakamura, Michiko, Tokunaga, Yumie, Nakamura, Masahiro, Watanabe, Akira, Yamanaka, Shinya, Takahashi, Kazutoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151758/
https://ncbi.nlm.nih.gov/pubmed/25097266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413299111
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