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Early identification of hERG liability in drug discovery programs by automated patch clamp
Blockade of the cardiac ion channel coded by human ether-à-gogo-related gene (hERG) can lead to cardiac arrhythmia, which has become a major concern in drug discovery and development. Automated electrophysiological patch clamp allows assessment of hERG channel effects early in drug development to ai...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151236/ https://ncbi.nlm.nih.gov/pubmed/25228880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00203 |
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