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Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay
AIM: hERG potassium channels display miscellaneous interactions with diverse chemical scaffolds. In this study we assessed the hERG inhibition in a large compound library of diverse chemical entities and provided data for better understanding of the mechanisms underlying promiscuity of hERG inhibiti...
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| Publicado no: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4722980/ https://ncbi.nlm.nih.gov/pubmed/26725739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.143 |
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