Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett’s metaplasia

Metaplasia can result when injury reactivates latent developmental signaling pathways that determine cell phenotype. Barrett’s esophagus is a squamous-to-columnar epithelial metaplasia caused by reflux esophagitis. Hedgehog (Hh) signaling is active in columnar-lined, embryonic esophagus and inactive...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, David H., Tiwari, Anjana, Kim, Monica E., Clemons, Nicholas J., Regmi, Nanda L., Hodges, William A., Berman, David M., Montgomery, Elizabeth A., Watkins, D. Neil, Zhang, Xi, Zhang, Qiuyang, Jie, Chunfa, Spechler, Stuart J., Souza, Rhonda F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151220/
https://ncbi.nlm.nih.gov/pubmed/25083987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66603
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