Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett’s metaplasia

Metaplasia can result when injury reactivates latent developmental signaling pathways that determine cell phenotype. Barrett’s esophagus is a squamous-to-columnar epithelial metaplasia caused by reflux esophagitis. Hedgehog (Hh) signaling is active in columnar-lined, embryonic esophagus and inactive...

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Detalhes bibliográficos
Main Authors: Wang, David H., Tiwari, Anjana, Kim, Monica E., Clemons, Nicholas J., Regmi, Nanda L., Hodges, William A., Berman, David M., Montgomery, Elizabeth A., Watkins, D. Neil, Zhang, Xi, Zhang, Qiuyang, Jie, Chunfa, Spechler, Stuart J., Souza, Rhonda F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151220/
https://ncbi.nlm.nih.gov/pubmed/25083987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66603
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