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Effect of a DNA Nuclear Targeting Sequence on Gene Transfer and Expression of Plasmids in the Intact Vasculature

Although the use of nonviral vectors for gene therapy offers distinct advantages including the lack of significant inflammatory and immune responses, the levels of expression in vivo remain much lower than those obtained with their viral counterparts. One reason for such low expression is that unlik...

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Библиографические подробности
Главные авторы: Young, Jennifer L., Benoit, Joseph N., Dean, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2003
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150867/
https://ncbi.nlm.nih.gov/pubmed/12900761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3302021
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