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Sequence requirements for plasmid nuclear import

The nuclear envelope is a major barrier for nuclear uptake of plasmids and represents one of the most significant unsolved problems of non-viral gene delivery. We have previously shown that the nuclear entry of plasmid DNA is sequence-specific, requiring a 366 bp fragment containing the SV40 origin...

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Detalhes bibliográficos
Main Authors: Dean, David A., Dean, Brenda S., Muller, Susanne, Smith, Louis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152905/
https://ncbi.nlm.nih.gov/pubmed/10585295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/excr.1999.4716
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