ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

Epithelial-mesenchymal transition (EMT) is associated with characteristics of breast cancer stem cells, including chemoresistance and radioresistance. However, it is unclear whether EMT itself or specific EMT regulators play causal roles in these properties. Here we identify an EMT-inducing transcri...

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Autori principali: Zhang, Peijing, Wei, Yongkun, Wang, Li, Debeb, Bisrat G., Yuan, Yuan, Zhang, Jinsong, Yuan, Jingsong, Wang, Min, Chen, Dahu, Sun, Yutong, Woodward, Wendy A., Liu, Yongqing, Dean, Douglas C., Liang, Han, Hu, Ye, Ang, K. Kian, Hung, Mien-Chie, Chen, Junjie, Ma, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150825/
https://ncbi.nlm.nih.gov/pubmed/25086746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3013
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