The Effect of CYP2D6 Drug-Drug Interactions on Hydrocodone Effectiveness

OBJECTIVES: The hepatic cytochrome 2D6 (CYP2D6) is a saturable enzyme responsible for metabolism of approximately 25% of known pharmaceuticals. CYP interactions can alter the efficacy of prescribed medications. Hydrocodone is largely dependent on CYP2D6 metabolism for analgesia, ondansetron is inact...

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Detaylı Bibliyografya
Asıl Yazarlar: Monte, Andrew A., Heard, Kennon J., Campbell, Jenny, Hamamura, D., Weinshilboum, Richard M., Vasiliou, Vasilis
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150819/
https://ncbi.nlm.nih.gov/pubmed/25156930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acem.12431
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