CYP2D6 Genotype Phenotype Discordance Due to Drug-Drug Interaction

Drug-drug interactions have been demonstrated to alter CYP2D6 enzyme phenotype due to inhibitor ingestion though it is unclear how substrate interactions affect phenotype. This was a pragmatic clinical trial examining the kinetics of a CYP2D6 enzyme probe drug with and without CYP2D6 dependent subst...

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Publicado en:Clin Pharmacol Ther
Main Authors: Monte, Andrew A., West, Kelsey, McDaniel, Kyle T., Flaten, Hania K., Saben, Jessica, Shelton, Shelby, Abdelmawla, Farah, Bushman, Lane R., Williamson, Kayla, Abbott, Diana, Anderson, Peter L.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197912/
https://ncbi.nlm.nih.gov/pubmed/29882961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1135
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